AICAR

AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a next-generation metabolic activator known for its ability to directly activate AMPK, the body’s primary energy-regulating enzyme.

By stimulating AMP-activated protein kinase, AICAR enhances fat oxidation, increases cellular energy, supports muscle performance, and promotes healthier metabolic function.

AICAR is widely studied for its role in metabolic enhancement, endurance improvement, insulin sensitivity support, and fat-loss acceleration—making it a powerful compound for research related to performance, longevity, and metabolic optimization.

Form & Stability

All Peptide Labs peptides are produced with 99%+ purity and lyophilized to preserve potency and stability.

• Unmixed (Freeze-Dried): Stable for up to 1 year in the refrigerator (2–8 °C / 36–46 °F) and over 5 years in the freezer (-20 °C / -4 °F).

• After Reconstitution: Store in the refrigerator (2–8 °C / 36–46 °F) and use within 30 days for optimal results.

Research Overview

1. AMPK Activation & Energy Regulation

AICAR’s primary function is to activate AMPK, the central metabolic regulator responsible for energy balance, glucose uptake, and fat utilization.
This action increases cellular energy production, enhances metabolic efficiency, and supports improved glucose control.

2. Fat Loss & Metabolic Efficiency

Research shows AICAR significantly improves:

• fatty acid oxidation,

• metabolic rate,

• carbohydrate utilization.

These mechanisms contribute to enhanced and consistent fat loss, even in low-activity environments, by mimicking several metabolic effects of exercise.

3. Muscle Performance & Endurance Enhancement

AICAR has been shown to:

• improve muscular endurance,

• increase resistance to fatigue,

• enhance ATP efficiency,

• support faster cellular recovery.

These effects make AICAR a major research interest for performance optimization and muscle energy management.

4. Insulin Sensitivity & Glucose Control

AICAR promotes healthier glucose metabolism by:

• increasing insulin sensitivity,

• enhancing glucose uptake in muscle cells,

• lowering fasting glucose levels in metabolic studies.

This improved glucose control supports long-term metabolic stability.

5. Cardiovascular & Cellular Health

Studies suggest AICAR may:

• enhance mitochondrial function,

• reduce cellular stress,

• improve lipid management,

• support cardiovascular efficiency.

This contributes to better metabolic and cellular performance during fat-loss or endurance phases.

6. Body Composition Enhancement

AICAR supports superior body composition through:

• reduction of fat mass,

• preservation of lean mass,

• improved metabolic efficiency,

• enhanced overall performance capacity.

Molecular Structure

• Molecular Formula: C₉H₁₄N₄O₅

• Molecular Weight: 258.23 g/mol

• Form: Lyophilized (freeze-dried) powder for maximum stability